The MiniMed Paradigm® REAL-Time Insulin Pump and Continuous Glucose Monitoring System

For the first time, REAL-Time continuous glucose monitoring is integrated with insulin pump therapy, for insulin management that works more like the systems of the human body. The introduction of the MiniMed Paradigm® REAL-Time system represents a major step forward in diabetes management by Medtronic Diabetes, the 20-year pioneer of insulin pump therapy and continuous glucose monitoring.

REAL-Time System Components Help Your Patients Better Manage Their Diabetes

System components include:

  • Glucose sensor
  • Radio frequency (RF) transmitter
  • MiniMed Paradigm 522 or 722 insulin pump
  • MiniMed Paradigm infusion sets
  • CareLink™ Personal Software

Continuous Glucose Sensor Provides REAL Insights

  • A small sensor inserts easily under the skin in a virtually painless process
  • Measures current glucose levels in interstitial fluid, as an adjunct to fingerstick measurements (fingersticks are required prior to adjusting insulin delivery and when calibrating the glucose sensor)
  • Accuracy is proven in numerous published studies1-3
  • Patients can shower, bathe or swim while wearing the sensor and transmitter
  • Glucose sensor can be used for up to 3 days

Radiofrequency (RF) Transmitter Allows REAL Flexibility

  • Enables system components to communicate wirelessly for optimal flexibility
  • Permits an active lifestyle: it is small, discreet and waterproof so your patient can wear it anytime, anywhere

MiniMed Paradigm 522 or 722 Insulin Pump Offers REAL Innovations

  • On-screen REAL-Time glucose readings, trend arrows, and trend graphs to help patients understand more about their glucose control and improve their diabetes management
  • Easy-to-use menu navigation
  • Millions of safety checks for safe, reliable use
  • Access to patient histories and retrospective continuous glucose trend analyses, downloaded from your patient's insulin pump to your computer. These insights can help you fine-tune basal rates and other settings more easily to optimize patient therapy more efficiently4-6

MiniMed Paradigm Infusion Sets Offer REAL Reliability

  • Provide the security of reliable insulin administration around the clock
  • Accommodate the unique needs of every patient, with a variety of customized infusion sets to choose from
  • Include automatic insertion devices, for virtually painless and reliable insertion

REAL Patient Histories with Retrospective Trend Graphs Improve Your Ability to Optimize Therapy

The Minimed Paradigm REAL-Time System includes special software that downloads insulin, carbohydrate, and glucose data directly from the insulin pump to provide more meaningful insights into patient progress than a logbook alone. Now you and your patients can discover and assess a wide range of glucose trends, like previously undetected overnight lows, to help optimize patient therapy more quickly and reduce the need for patient office visits.

Learn more about CareLink Pro software

REAL Benefits - Day and Night - for You and Your Patients

With the MiniMed Paradigm REAL-Time System, patients have access to REAL-Time glucose readings, trending and alarms around the clock so they can intervene more quickly. Also, with the special software included with the system, you and your patients can review insulin, carbohydrate and glucose data and improve awareness of glycemic patterns. This information can help you and your patients better detect and manage incidents of hypo- and hyperglycemia, which can reduce HbA1c levels7-9 and related diabetes complications.10,11

System features include:

  • REAL-Time Trend Graphs
  • REAL-Time Readings
  • REAL-Time Trend Arrows
  • REAL-Time Alarms
  • REAL Patient Historical Information
  • Bolus Wizard® Calculator

REAL-Time Trend Graphs

  • Viewable on-screen
  • 3-hour and 24-hour glucose trending
  • Show patients the effect of meals, exercise, insulin and medication on their glycemic control
  • CareLink Personal software helps you and your patients to easily manage this data online so that together you can better manage their diabetes

REAL-Time Readings

  • Available every 5 minutes, 24 hours a day
  • Up to 288 readings per day
  • Viewable on-screen at work, during mealtime and when exercising
  • Help patients increase awareness, be proactive, and improve glycemic control12-14

REAL-Time Trend Arrows

  • Point up or down to reveal the direction and degree of change of glucose trends
  • Increase awareness of glucose variability
  • Enable patients to address even brief fluctuations in glucose levels, which can impact the development of long-term diabetes complications like eye, nerve, kidney and heart disease15,16

REAL-Time Alarms

  • Warn patients of hyperglycemia and hypoglycemia day or night, that may not be revealed when using fingersticks alone or HbA1c testing17
  • Can be preset to sound or vibrate and are easily customized to different thresholds of sensitivity
  • Patient response to REAL-Time alarms results in a significant reduction in the duration of hypoglycemic excursions17

REAL Patient Historical Information

  • You and your patients can easily download information using Therapy Management Software including Solutions Software for Pumps and Meters and CareLink Personal software.
  • Gain insights needed to optimize patient therapy more quickly and give patients the knowledge they need to take more responsibility for their diabetes management

Bolus Wizard Calculator

  • The MiniMed Paradigm REAL-Time System includes a patented dosing calculator that does the diabetes math for patients to help reduce math errors, improve dosage accuracy, and avoid post-prandial hypoglycemia18
  • Uses a patient's personal settings, blood glucose reading, carbohydrate entry, and active insulin levels to suggest a bolus amount
  • Factors in a patient's preset blood glucose target range when calculating a bolus dose to help patients "treat to target" and improve their glycemic control18,19

The Bolus Wizard does the math for diabetes patients

1
Steil GM, Bernaba B, Saad M, et al. Accurate determination of plasma glucose during hyper- and hypoglycemia with a subcutaneous glucose sensor. Diabetes. 2000;49(Suppl 1):510.
2
Gross TM, Mastrototaro JJ. Efficacy and Reliability of the Continuous Glucose Monitoring System. DiabetesTechnol Ther. 2000;2(Suppl 1):S19-26.
3
Caplin NJ, O'Leary P, Bulsara M, et al. Subutaneous glucose sensor values closely parallel blood glucose during insulin-induced hypoglycemia. Diabet Med 2003;20:238-41.
4
Bode BW, Gross TM, Thornton KR, et al. Continuous glucose monitoring used to adjust diabetes therapy improves glycosylated hemoglobin: a pilot study. Diabetes Research and Clin Practice. 1999;46:183-90.
5
Kaufman FR, Gibson LC, Halvorson M, et al. A pilot study of the continuous glucose monitoring system: clinical decisions and glycemic control after its use in pediatric type 1 diabetic subjects. Diabetes Care. 2001;24(12):2030.
6
Ludvigsson J, Hanas R. Continuous subcutaneous glucose monitoring improved metabolic control in pediatric patients with type 1 diabetes: a controlled crossover study. Pediatrics. 2003 May;111(5 Pt 1):933-8.
7
Bode BW, Gross TM, Thornton KR, et al. Continuous glucose monitoring used to adjust diabetes therapy improves glycosylated hemoglobin: a pilot study. Diabetes Research and Clin Practice. 1999;46:183-90.
8
Kaufman FR, Gibson LC, Halvorson M, et al. A pilot study of the continuous glucose monitoring system: clinical decisions and glycemic control after its use in pediatric type 1 diabetic subjects. Diabetes Care. 2001;24(12):2030.
9
Ludvigsson J, Hanas R. Continuous subcutaneous glucose monitoring improved metabolic control in pediatric patients with type 1 diabetes: a controlled crossover study. Pediatrics. 2003;111(5 Pt 1):933-8.
10
American Diabetes Association: Standards of Medical Care for Patients with Diabetes Mellitus. Diabetes Care. 2002;25(1):S33-49.
11
Lifetime benefits and costs of intensive therapy as practiced in the diabetes control and complications trial. The Diabetes Control and Complications Trial Research Group. JAMA. 1997;277(5):374-5.
12
Bode BW, Gross TM, Thornton KR, et al. Continuous glucose monitoring used to adjust diabetes therapy improves glycosylated hemoglobin: a pilot study. Diabetes Research and Clin Practice. 1999;46:183-90.
13
Kaufman FR, Gibson LC, Halvorson M, et al. A pilot study of the continuous glucose monitoring system: clinical decisions and glycemic control after its use in pediatric type 1 diabetic subjects. Diabetes Care. 2001;24(12):2030.
14
Ludvigsson J, Hanas R. Continuous subcutaneous glucose monitoring improved metabolic control in pediatric patients with type 1 diabetes: a controlled crossover study. Pediatrics. 2003;111(5 Pt 1):933-8.
15
Derr R, Garrett E, Stacy G, et al. Is HbA1c affected by glycemic instability? Diabetes Care. 2003;26(10): 2728-33.
16
Lifetime benefits and costs of intensive therapy as practiced in the diabetes control and complications trial. The Diabetes Control and Complications Trial Research Group. JAMA. 1997;277(5):374-5.
17
Bode B, Gross K, Rikalo N, et al. Alarms based on real-time sensor glucose values alert patients to hypo- and hyperglycemia: the guardian continuous glucose monitoring system. DiabetesTechnol Ther. 2004;6(2):105-13.
18
Gross T, Kayne D, King A, et al. A bolus calculator is an effective means of controlling postprandial glycemia in patients on insulin pump therapy. Diabetes Technol Ther. 2003;5(3):365-9.
19
Mudaliar SR, Lindberg FA, Joyce M, et al. Insulin aspart (B28 asp-insulin): a fast-acting analog of human insulin: absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects. Diabetes Care. 1999;22(9):1501-6.